Faculty Of Medicine

Blog For Young Doctors And Medical Students.

Gene therapy and cancer

By/ Dr.Waled Tarek

Gene therapy is the insertion, alteration, or removal of genes within an individual's cells and biological tissues to treat disease


Mutations are changes in a genomic sequence “DNA sequence of a cell's genome or the DNA or RNA sequence of a virus”. These may have no effect, alter the product of a gene, or prevent the gene from functioning properly or completely.

A gene is a unit of heredity in a living organism.

DNA replication:
DNA is replicated so that each new cell recieves a complete copy of original cell's genetic information.

The genetic code:
It's the arrangement of a particular sequence of nucleotide in the DNA which is transcribed to a complementary sequence in mRNA which goes to ribosomes where it's translated into a particular sequence of amino acids in a polypeptide which makes a particular protien

Types of gene therapy:
1-germ like gene therapy
2-somatic gene therapy

Cancer genome:
The Cancer Gene (Census) is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer