By/ Dr.Waled Tarek
Gene therapy is the insertion, alteration, or removal of genes within an individual's cells and biological tissues to treat disease
Definitions:
Mutation:
Mutations are changes in a genomic sequence “DNA sequence of a cell's genome or the DNA or RNA sequence of a virus”. These may have no effect, alter the product of a gene, or prevent the gene from functioning properly or completely.
Genes:
A gene is a unit of heredity in a living organism.
DNA replication:
DNA is replicated so that each new cell recieves a complete copy of original cell's genetic information.
The genetic code:
It's the arrangement of a particular sequence of nucleotide in the DNA which is transcribed to a complementary sequence in mRNA which goes to ribosomes where it's translated into a particular sequence of amino acids in a polypeptide which makes a particular protien
Types of gene therapy:
1-germ like gene therapy
2-somatic gene therapy
Cancer genome:
The Cancer Gene (Census) is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer
